Search terms combined keywords related to Ph-MPNs (“Philadelphia-negative myeloproliferative neoplasms,” “Ph-negative MPN,” “JAK2 mutation”), immune and inflammatory dysregulation (“immune dysfunction,” “inflammatory dysregulation,” “immune dysregulation”), the specific MPN subtypes (“polycythemia vera,” “essential thrombocythemia,” “primary myelofibrosis”), immune parameters (“lymphocyte subsets,” “cytokine profiling,” “immune markers”), and novel immunomodulatory therapies (“targeted therapies,” “immune modulators”). Here, JAK2 is linked to essential thrombocythemia.