In addition, our results are in line with some [3,6] but not all [4] clinical studies that showed, by using the modern liquid chromatography–tandem mass spectrometry (LC-MS/MS) assay, that 11-oxygenated androgens, which have an adrenal source, are positively correlated with insulin and HOMA-IR [6] or obesity [3] in PCOS. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.