POMC and Insulin resistance: Moreover, our results are in line with previous in vivo PCOS data that suggest the effect of insulin on amplifying adrenal steroidogenesis in response to ACTH [17,18,36] and are consistent with the ability of insulin-sensitizing drugs to decrease adrenal hyperandrogenism in parallel with a decrease in insulin resistance and hyperinsulinemia in women with PCOS and in a nonhuman primate model of PCOS [37,38,39,40].