SULT2A1 and polycystic ovary syndrome: However, since PCOS involves common genetic factors that affect both adrenal and ovarian androgen synthesis [1], and unsurprisingly, DHEAS correlated significantly with TT and FAI in the bivariate analysis of our cases, we included these parameters in multivariate stepwise regression models, and 2 h insulin in the OGTT still remained an independent predictor of DHEAS in PCOS.