The pathogenic mechanisms of association between hyperinsulinemia and adrenal hyperandrogenism are not fully understood; however, previous in vitro experiments demonstrate the ability of insulin-like growth factors (insulin, IGF-I or IGF-II) to enhance the steroidogenesis and ACTH responsiveness of human adrenocortical cells in culture [43]. The gene discussed is IGF2; the disease is Adrenal Hyperandrogenism.