In addition, PCOS patients with high DHEAS values had significantly higher serum concentrations of 2 h insulin in the OGTT than PCOS patients with low DHEAS concentrations, in line with results published by Alpañés M et al. The authors defined adrenal hyperandrogenism (AH) in PCOS by using the 95th DHEAS percentile of a control population and found that PCOS women with AH had higher circulating insulin levels and lower insulin sensitivity than their non-AH PCOS counterparts [14]. This evidence concerns the gene INS and Adrenal Hyperandrogenism.