While the etiology of erosive gastritis can be multifactorial, current major clinical practice guidelines, including those from the American College of Gastroenterology (ACG), and the Asian Pacific Association of Gastroenterology (APAGE), primarily focus on treating specific underlying causes, such as Helicobacter pylori infection, the prevention of ulcers in patients using NSAIDs or acid-suppressive agents such as proton pump inhibitors (PPIs) and histamine H2 receptor antagonists (H2RAs) for acid-related disorders such as gastroesophageal reflux disease (GERD) [6,7,8]. Here, HRH2 is linked to gastroesophageal reflux disease.