Protein trios allowing 88% accuracy of correct classification are coagulation factor XIII + eukaryotic translation initiation factor 2 subunit 3 & Ras GTP-ase-activating-like protein IQGAP2.F-actin-capping protein & myosin light chain kinase.Septin-7 & gamma-adducin.When integrating protein trio 1 + history of cardiac failure + protein concentration, the accuracy improved to 97%. The gene discussed is SEPTIN7; the disease is heart failure.