TRIM21 and Sjogren syndrome: These include advanced age, male sex, smoking history, higher ESSDAI (EULAR Sjögren’s syndrome disease activity index), prolonged disease course, coexistence of other autoimmune conditions, elevated inflammatory markers (erythrocyte sedimentation rate—ESR, C-reactive protein—CRP), signs of lymphocytic activation, such as autoantibody positivity (Anti-Ro/Ssa—especially Ro-52; Anti-La/SSb) or hypergammaglobulinemia [21,32,49].