C3 and Hepatic fibrosis: The first reports on the use of collagen biomarkers in the assessment of liver fibrosis appeared at the turn of the 20th and 21st centuries [78,80,81,82], but groundbreaking research on PRO-C3 (collagen neoepitope biomarker PRO-C3) and the ADAPT system (a PRO-C3-based score) has been published in the last 10–15 years [83,84,85].