To date, evaluation of tumor-specific intraoperative tumor and margin detection in bladder and kidney cancer remains limited to a few (ex vivo) examples [41,79], Still in the results obtained with PSMA indicating a promising avenue for exploring tumor targeted hybrid tracers in future research and clinical applications in bladder and kidney cancer as well, particularly with the aim to visualization of tumor margins and aid in tumor identification in partial nephrectomies. This evidence concerns the gene FOLH1 and kidney cancer.