In the study conducted by Ozyildirim et al., higher creatinine (1.5 mg/dL vs. 1.15 mg/dL, p = 0.001) and Gal-3 levels (20.7 ± 2.9 ng/mL vs. 17.8 ± 3.1 ng/mL, respectively; p < 0.001) were found in HFrEF patients who developed CRS [78]. Here, LGALS3 is linked to congenital rubella syndrome.