LGALS3 and Abnormal renal physiology: Additionally, in the Framingham Offspring Study, patients with baseline Gal-3 in the highest quartile and normal renal function (mean eGFR~90 mL/min/1.73 m2) had significantly higher odds of developing incident renal dysfunction, which was defined as an eGFR < 60 mL/min/1.73 m2 (adjusted OR = 1.47, 95% CI 1.27–1.71, p < 0.0001) [81].