To assess current literature on potential markers for altered fibrinolysis in sepsis, we conducted a literature search in PubMed on 16 June 2025 using the following search terms: “sepsis”, “septic shock”, “fibrinolysis”, “PAI-1”, “plasminogen activator inhibitor”, “thromboelastometry”, “thrombelastography”, “clot lysis” in various combinations. This evidence concerns the gene SERPINE1 and Sepsis.