-enhanced antitumor properties of anticancer drugs-induced apoptosis and autophagy, cell cycle arrest, inhibited tumor proliferation, invasion, and metastasis, as well as immunological damage through inhibition of coupling of β-adrenergic and muscarinic receptors to G proteins, BPNT1, GSK-3β, MYCN, modification of WNT/β-catenin, CREB, and immunomodulation of lymphokine killer cells. This evidence concerns the gene CREB1 and neoplasm.