STAT3 and ear infection: They reduced the National Institute of Health (NIH)’s 20 clinical features to five key indicators, including (i) lung abnormalities, (ii) eosinophilia, (iii) upper respiratory infections, (iv) retained primary teeth, and (v) fractures with minimal trauma, achieving a sensitivity of 91.4% and specificity of 87.5% [with eosinophilia and upper respiratory infections (sinusitis and otitis) more prevalent in DOCK8 deficient patients, while the others more prevalent in STAT3 deficiency].