NVL and cancer: Recent evidence indicates that certain emerging autoantibodies may help stratify malignancysusceptibilityin SSc: anti-RNPC-3 (also known as anti-U11/U12) and anti-NVL (nuclear valosin-containing protein-like) have been linked to a higher likelihood of malignancy, particularly in cases with synchronous cancer [67,68] while anti-RPA194 (RNA polymerase I) and anti-Th/To may be associated with a reduced probability [69,70].