In accordance with the previous studies, we found that PLHIV with lower CD4+ cell counts were more likely to be diagnosed with cryptococcal meningitis (t = 4.799, p = 0.001), esophageal candidiasis (t = 3.382, p = 0.001), PJP (t = 4.572, p = 0.000), and oral candidiasis (t = 4.273, p = 0.000). Here, CD4 is linked to Cryptococcal meningitis.