Currently, B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NTproBNP)), in addition to cardiac troponins, are well-established markers for the diagnosis of heart failure and acute coronary syndromes, respectively [19,20], and have been incorporated into numerous international clinical guidelines [21,22]. The gene discussed is NPPB; the disease is acute coronary syndrome.