Studies using various animal models, including Flinders Sensitive Line rats (a genetic model of depression), low-density lipoprotein receptor knockout (LDLR−/−) mice (a model of hypercholesterolemia and atherosclerosis) or mice fed a high-fat diet (HFD; a diet-induced model of obesity and metabolic syndrome) have demonstrated a correlation between high cholesterol levels and behavioral symptoms, resembling anxiety-like behaviors and depressive disorders [15,16,17]. This evidence concerns the gene LDLR and depressive disorder.