The observed alterations in FGF-2, FGF-19, FGF-22, and FGF-23 concentrations—particularly their associations with hypertension, obesity, nephropathy, and joint degeneration—support their role not only in the pathogenesis but also in the clinical stratification of diabetic complications. Here, FGF2 is linked to obesity due to melanocortin 4 receptor deficiency.