TNF and skin cancer: It is a safe agent preventing UVB-induced skin cancer via targeting inflammatory mediators (lowering COX-2, PGE2, PCNA, TNF-α, IL-1β, and IL-6 levels), cell cycle regulators (CDK inhibitor upregulation), and cell survival signals (cyclins D1, D2, E2 and CDKs2, 4, 6 inhibition).