The validation analysis adjusting the correlation for the influential factors, such as age and MS duration, of MS confirms that the strongest relationship is between SEMA3A and neurofilaments (multiple correlation coefficient = 0.44) and between progranulin and IL-6 (0.39) in the SPMS cohort and the strongest relationship is between SEMA3A and neurofilaments (0.25) in RR MS patients. Here, GRN is linked to myeloid sarcoma.