SMAD3 and rheumatoid arthritis: The abnormal excessive signaling in OA might be due to TLR9 and TLR3 SNPs, associated with OA risk [60,61], numerous gene mutations of the factors of TGF cascade associated with cartilage thickness, erosive hand OA or hip minimal joint space width (PIK3R1, SMAD3, CEMIP (KIAA1199) BMP6, and NOG) partly presented in Supplementary Table S1 [62,63,64,65] and probably HIF SNP (contradictory data) associated with OA and RA disease risk [66,67].