The same pannus types, and additionally, with similar qualitative metabolic characteristics and pro-inflammatory cytokine response (IL-1beta, IL-8, IL-10, IL-12, TNF-alpha, IFN-gamma determined in supernatants of tissue cultures and COMP, type II collagen, TNF-alpha, IL-10, and Ki-67 expression detected by immunohistochemistry), were described by Furuzawa-Carballeda et al. in synovial samples of late OA and RA obtained during arthroplasty [400]. This evidence concerns the gene IL10 and rheumatoid arthritis.