Another important sign of pannus expression of antiapoptotic and prooncogenic factors demonstrated both in RA and OA synovial samples—in particular, oncofetal glycosylated Fn in correlation with hyperplasia [403]; Ki-67 both in RA (26.6-fold vs. histologically normal synovium) and OA (3.9-fold) pannuses [404]; and metastasis-associated protein S100A4 in RA and OA synovial tissues, in contrast with normal synovium [405]. The gene discussed is LYPD5; the disease is rheumatoid arthritis.