ANAPC4 and rheumatoid arthritis: Additionally, anaphase-promoting complex subunit 4 (ANAPC4), SUMO-specific peptidase 1 (SENP1), DLG-associated protein 2 (DLGAP2), BLK proto-oncogene, Src family tyrosine kinase (BLK), and PTPRM-coded factors are implicated in the dysregulation of apoptotic pathways, disrupting cell cycle regulation in synovial cells, causing increased apoptosis in chondrocytes contributing to cartilage loss in OA and disturbed cell cycling in synovial fibroblasts, and promoting hyperplasia in RA (Supplementary Table S1).