TGF-β, HIF-1α, and miRNAs form a complex feedback loop, where TGF-β can induce the expression of miRNAs that negatively regulate HIF-1α, while HIF-1α can influence TGF-β signaling and miRNA synthesis, creating a dynamic balance that contributes to cellular plasticity and tumor progression [58,59,60]. Here, TGFB1 is linked to neoplasm.