Building on that work, the present study analyzed the different molecular expression patterns of ALS (ALS1, ALS2, ALS3, ALS4, ALS5, ALS6, ALS7, and ALS9) and SAP (SAP1-SAP10) family genes in C. albicans strains isolated from patients with periodontal disease in an in vitro infection model using an HGF cell line. This evidence concerns the gene SPG11 and infection.