This review aims to provide a comprehensive analysis of selected CXC chemokines, both ELR+ and ELR- (CXCL1, CXCL8, CXCL12, CXCL13, CXCL14, and CXCL16), along with their corresponding receptors, in the context of CRC. This evidence concerns the gene CXCL14 and colorectal carcinoma.