Recruit TAMs into the tumor via increased IL-1, IL-6 and TNF-α production.In CRCLM blockade of CXCL12 increases M1/M2 macrophage ratio, shifting towards anti-tumor phenotype.CXCL1 produced by TAMs recruits CXCR2+ MDSCs for the pre-metastatic niche to stimulate liver metastases in CRC. This evidence concerns the gene IL1A and colorectal carcinoma.