Moreover, a first phase 1/2 study assessed the safety, tolerability, and toxicity of a single intravitreal injection of siRNA-027 (AGN211745) (NCT00363714), a siRNA targeting VEGFR-1, together with associated anatomical changes in the retina and in visual acuity in age-related macular degeneration (AMD). The gene discussed is FLT1; the disease is age-related macular degeneration.