Among the various autoantibodies, anti-double-stranded DNA antibodies (anti-dsDNA) play an important role in both the pathogenesis and the diagnosis of SLE; its IgG form was first identified in the serum of SLE patients in 1957 by four different groups [2,3], whilst its IgM and IgA counterparts required a few more decades to be properly assessed [3]. The gene discussed is CD40LG; the disease is systemic lupus erythematosus.