The possibility of a non-invasive diagnosis of membranous nephropathy also in anti PLA2R negative patients through the analysis of urinary exosomes could become a reality, as reported by Wang et al. [29] who observed an overexpression of Alix, CD63, and TSG101 in urinary exosomes of patients with membranous nephropathy compared to healthy controls. This evidence concerns the gene PLA2R1 and membranous glomerulonephritis.