MYC and retinoblastoma: A concise visual summary integrating these transcriptomic insights illustrates the key molecular characteristics of MYCN-driven retinoblastoma: activation of MYC/E2F transcriptional networks, enhanced proliferation and mTORC1 signaling, increased neural/RGC-associated transcription factors, and diminished expression of photoreceptor-specific genes, collectively reflecting a shift toward a proliferative, undifferentiated retinal progenitor-like state (Figure 3F).