However, in this regard, it should be noted that the scope of this work was to characterise key phenotypic alterations in the CNS of PAC1−/− mice (as well as PAC1+/− mice) to help unveil the importance of PAC1 receptors in CNS homeostasis and/or vulnerability to neurological conditions, including but not limited to MS. This evidence concerns the gene ADCYAP1R1 and myeloid sarcoma.