Similarly, the increase in MMP-14 expression detected under combined treatment in 3D spheroids may reflect altered, context-dependent responses specific to 3D systems. Figure 8 provides a summary of the dual receptor targeting concept in breast cancer (Figure 8A) and highlights the main results obtained from applying this approach in TNBC spheroid models of different aggressiveness (Figure 8B). This evidence concerns the gene MMP14 and breast carcinoma.