Popular cell line models include BV-2 (mouse, microglia), HL-60 (human, promyelocytic leukaemia monocyte-like line from which CB2 was first cloned) [160], J774 (mouse, macrophage), N9 (mouse, microglia), RAW 264.7 (mouse, monocyte/macrophage), spontaneously immortalised microglia (SIM)-A9 (mouse), THP-1 (human, monocytic leukaemia), and U937 (human, monocytic leukaemia). This evidence concerns the gene CNR2 and monocytic leukemia.