In a pilocarpine-induced chronic epilepsy mouse model, treatment with the CB2-selective agonist, AM1241 (1 mg/kg/day i.p. from 8th day after induction of status epilepticus), reduced NLRP3 inflammasome activation and suppressed inflammatory markers in hippocampal microglia, which was accompanied by decreased neuronal loss, seizure frequency, and depressive-like behaviour in mouse model [216]. The gene discussed is CNR2; the disease is status epilepticus.