Although the effects of CB2 activity on the typical functions of macrophages and its regulation of specific signalling pathways remain incompletely understood, several studies have demonstrated therapeutic effects of CB2-targeted compounds mediated through macrophages, particularly microglia, in the contexts of infectious diseases, neuropathic pain, neurodegenerative diseases, and autoimmunity, as well as non-neuronal organ injury, chronic inflammation, and cancer. This evidence concerns the gene CNR2 and neurodegenerative disease.