P2RX7 and Parkinson disease: Since MPP+/MPTP can modulate the P2X7 receptor and upregulate the expression of P2X7Rs, as demonstrated in studies involving in vitro PC12 neuronal cells causing the process of neuroinflammation [39], one of the probable mechanisms of neuroprotection from the damaging effect of the neurotoxin MPP+ in the PD model in vivo may not only be the antioxidant activity of U-573, but also its ability to block the functioning of P2X7Rs, the overactivation and/or overexpression of which leads to the development of this disease.