In the hepatocytes, miR-34a inhibit SIRT1, contributing to steatosis development via Sterol regulatory element binding proteins (SREBPs), Peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α), Liver X Receptors (LRXs) and forkhead box protein O1 (FOXO-1) [13,43,44]. This evidence concerns the gene PPARGC1A and steatosis.