HDAC6 and early-onset autosomal dominant Alzheimer disease: The authors showed that hydroxamic acid with an adamantane moiety linked by an amide bond to a carbohydrate linker effectively inhibits HDAC6 by forming hydrogen bonds with HIS610, HIS651, and TYR782 of the catalytic center of HDAC6 and hydrophobic interactions with PRO608, PHE620, PHE679, PHE680, LEU749, and EHK782 and is a potential agent against Alzheimer’s disease.