This is evidenced by the dose-dependent reduction in the serum levels of the IL-10 (M2-specific cytokines) and Arg-1 (hallmark marker for M2 macrophages) following L-K5 treatment (Figure 1C,D), which correlated with inhibited tumor growth and reduced liver metastasis (Figure 1A,B). This evidence concerns the gene ARG1 and neoplasm.