Additionally, FL5 suppresses proinflammatory pathways (Mincle, Syk, NF-κB) in macrophages, modulates the inflammatory response in sepsis, and regulates autophagy in diabetic nephropathy and renal fibrosis contexts, reducing TGF-β expression and epithelial–mesenchymal transition [15]. The gene discussed is TGFB1; the disease is diabetic kidney disease.