FL3 (Isoflavone): Isoflavone, a subclass of phytoestrogens, play a crucial role in suppressing the expression of biomarkers associated with inflammation and renal fibrosis, such as angiotensinogen (AGT), which contributes to renal damage in diabetic nephropathy through activation of the intrarenal renin-angiotensin system (RAS) [33]. The gene discussed is AGT; the disease is diabetic kidney disease.