Recent in silico bioinformatics analyses based on data derived from the TCGA database identified HNRNPL, PCBP1 (Poly (RC) Binding Protein 1), and RER1 (Retention in endoplasmic reticulum sorting receptor 1) as novel pan-cancer reference genes; this was subsequently successfully validated in an array of human cancerous tissues [125]. The gene discussed is HNRNPL; the disease is cancer.