NOTCH3 and neoplasm: Epigenetically regulated miRNAs such as miR-206, let-7i, and miR-30c-5p play important tumor-suppressive roles in CRC, with miR-206 silenced via promoter hypermethylation and acting through inhibition of Notch3 and Wnt/β-catenin signaling, while let-7i and miR-30c-5p have been recently linked to chromatin remodeling, EMT suppression, and improved patient survival [57,60].