Contrast-enhanced ultrasound (CEUS) imaging with these microbubbles showed a negative correlation between targeted ultrasound intensity and the inflammatory tumor immune microenvironment, as well as cytotoxic T cell infiltration indicating that elevated CD93 expression in tumor vasculature correlates with a poor immune response in prostate cancer, positioning CD93 on ECs as a distinct marker of an immunosuppressive microenvironment [195]. The gene discussed is CD93; the disease is Familial prostate cancer.