Furthermore, Langenkamp et al. assessed vascular CD93 expression in lesion samples from 235 high-grade astrocytoma patients using immunohistochemistry and found that higher CD93 expression in blood vessels was associated with poorer survival, with high-grade gliomas exhibiting a greater prevalence of CD93 positivity compared to low-grade gliomas [48]. Here, CD93 is linked to central nervous system cancer.