CD93 and cancer: In 2013, Masiero et al. identified the angiogenic/vasculogenic gene signatures in human tumor samples from different cancer types, including head and neck squamous cell carcinomas (HNSCCs), breast cancers (BCs), and clear cell renal cell carcinomas (CCRCCs), and found that CD93 was significantly upregulated on tumor-associated ECs and was one of the top 20 genes associated with tumor angiogenesis [156].