IL6 and schizophrenia: Further evidence, while confirming that schizophrenia patients have higher levels of IL-6 than healthy controls, have documented a significant increase in IL-1 receptor antagonist (IL-1RA)—an endogenous inhibitor of the pro-inflammatory cytokine IL-1 effect- in TRS patients compared with healthy controls and non-TRS patients, together with a specific activation of the monocytic arm of cell-mediated immunity [186,201].