Studies revealed that individuals with schizophrenia exhibit multisystem biological dysregulations in peripheral blood, with alterations in circulating immune system proteins and elevated levels of IL-6 in both peripheral blood and CSF, suggesting a potential causal relationship between the IL-6/Interleukin-6 receptor (IL-6R) pathway and schizophrenia [194]. This evidence concerns the gene IL6R and schizophrenia.