– Enrichment for common SCZ risk variants (e.g., DRD2, COMT Val158Met, GRM3); – PRS indicates increased liability to psychosis compared with general population; – Rare but high risk CNVs (e.g., 22q11.2, 15q13.3, NRXN1 delections) contribute to SCZ risk;. This evidence concerns the gene COMT and psychotic disorder.