This complex induces the dissociation of the ZO-1 and ZONAB proteins from the junction complex and facilitates their translocation to the nucleus, where they function as a coactivator (ZO-1) and a transcription factor (ZONAB) for genes involved in proliferation and survival in breast cancer, such as human epidermal growth factor 2 (HER2). This evidence concerns the gene TJP1 and breast cancer.