Lee et al. (2022) [57] used nanoparticles loaded with a chemotherapeutic drug that targets microtubules, named paclitaxel (PTX), and the PS drug chlorin e6 (Ce6) for treating TME hypoxia and showed a reduction in cell viability and inhibition in tumor growth via activation of the p53 signaling pathway. The gene discussed is TP53; the disease is neoplasm.