Compared with the HF group, the HF-RES group depicted upregulated expressions of atf6, bcl-2, ppar-α, ppar-β, and cyp7a1, indicating that RES can promote hepatic fatty acid β-oxidation and bile acid synthesis by improving HF diet-induced ERS via m6A methylation, thus alleviating lipid metabolism disorders in M. amblycephala. Here, ATF6 is linked to hydrops fetalis.