As illustrated in Figure 3D–F,J–L, compared with the HF group, the HF-RES group displayed upregulated expression levels of junctional adhesion molecule 2 (jam2) (p < 0.01), zonula occludens 1 (zo1), and claudin41 (p < 0.05), and downregulated expression levels of toll-like receptor 4 (tlr4) (p < 0.05), nuclear factor kappa-B (nf-κb) and interleukin-1beta (il-1β) (p < 0.01). The gene discussed is TJP1; the disease is hydrops fetalis.