MeRIP-seq analysis indicated that RES modulated intestinal mRNA m6A methylation by upregulating methyltransferase-like 3 (mettl3) and downregulating fat mass and obesity-associated gene (fto) and Alk B homolog 5 (alkbh5). The gene discussed is ALKBH5; the disease is obesity due to melanocortin 4 receptor deficiency.