Among 24 glutamatergic DEGs in A20 and/or AD mice, there were seven genes coding for metabotropic receptors (Grm1, Grm2, Grm3, Grm4, Grm5, Grm7, and Grm8), 12 genes encoding ionotropic receptors (Gria3a Gria4, Grid1, Grid2ip, Grik1, Grik3, Grik4, Grik5, Grin1, Grin2a, Grin2d, and Grin3a), two genes encoding glutamate decarboxylase (Gad1 and Gad2), and two genes coding for inorganic transporters, Slc17a7 and Slc17a8 (Supplementary Table S1). This evidence concerns the gene GRM2 and Alzheimer disease.