Postmortem studies in patients with Alzheimer’s disease have revealed significantly reduced levels of DHEAS in the striatum, cerebellum, and hypothalamus and suggest that cognitive decline in Alzheimer’s disease may be more closely associated with reductions in DHEAS concentrations, or a decreased DHEAS-to-DHEA ratio, rather than absolute DHEA levels alone [60]. Here, SULT2A1 is linked to early-onset autosomal dominant Alzheimer disease.