Therefore, it was important to explore the differences in the expression levels of certain antiviral (such as IFN-β1, IFIT1, and RIG-I), pro-apoptotic (such as p53), and metastatic (such as N-cadherin) genes in the two cancer cell lines: the less susceptible to rVSV oncolysis B16-F10 and the very sensitive to this action LL/2. This evidence concerns the gene TP53 and cancer.