Furthermore, curcumin is well known to reduce the levels of nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB) and ROS [35] in experimental models of AMD, but to date, it has not been clarified whether curcumin targets single downstream events of the SIRT1-mediated enzymatic cascade, or whether its pleiotropic effect may be the result of the regulation of SIRT1 itself. The gene discussed is SIRT1; the disease is age-related macular degeneration.