SREBF1 and type 2 diabetes mellitus: In type 2 diabetes (T2D), insulin resistance stimulates hepatic lipogenesis through persistent Sterol Regulatory Element-Binding Protein 1c (SREBP-1c) activation and increased free fatty acid from adipose tissue lipolysis, resulting in the classic triad of hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C), and small dense LDL-C particles [5,6,7].