Mutations in the TP53 gene, leading to p53 deficiency, are the most common mutations in oral squamous cell carcinoma (OSCC) [32] and occur in over 50% of human cancers [33].The p53 deficiency also serves as an anti-apoptotic mechanism, as p53 normally binds to and suppresses BCL-w and BCL-XL, in coordination with p21, to release BAX and activate pro-apoptotic functions [34]. Here, TP53 is linked to cancer.