In this study, we specifically assess the Dox-induced enrichment of TGF-β and other pro-tumorigenic cytokines, including vascular endothelial growth factor (VEGF), Stromal cell-derived factor 1 (CXCL12), Growth-regulated alpha protein (CXCL1), C-C motif chemokine 5 (CCL5), Interleukin-3 (IL-3), Interleukin-4 (IL-4), Interleukin-10 (IL-10), Galectin-3, and Kit ligand (KITLG), which may facilitate angiogenesis, immune evasion, and stromal activation—hallmarks of tumor progression. This evidence concerns the gene CXCL12 and neoplasm.