MDK and crescentic glomerulonephritis: For example, Kojima et al. reported increases in inflammatory cell infiltration and matrix deposition in the glomerulus and the interstitium during the progression of crescentic glomerulonephritis induced by anti-glomerular basement membrane antibody in Mdk KO mice, showing that deficiency of MDK exacerbates necrotizing glomerular injuries in progressive glomerulonephritis [27].