NKX2-1 and cystic fibrosis: Jacob et al. generated dual-targeted iPSCs with NKX2-1GFP+/SFTPCtdTomato+ reporters and found that SFTPC-expressing cells from NKX2-1 precursors promoted distal airway patterning and alveologenesis [62], highlighting differentiated AEC2 as a reliable surrogate for investigating alveolar disease such as cystic fibrosis.